Ramos, 34, and Vazquez, 29, are both out of contract at the end of the season and their futures remain uncertain.
Reports suggest Ramos has turned down a one-year deal from Madrid, the club he arrived at in 2005.
Asked about Ramos and Vazquez possibly not signing contracts, Zidane said: "I don't want it but, in football, you never know.
"What I want and what we want you already know. You will ask me again at another press conference after the match and I will tell you the same thing. What I hope is that this will be sorted out, nothing more."
Eden Hazard's future is again a talking point at Madrid and the playmaker last started a league game in November.
But Zidane is unwilling to take risks with the 30-year-old, who has struggled with injuries since arriving at the club.
"He is with us. He is training regularly, then after that I don't know," he said.
"We will see if he is for 90 minutes or not and we will see how the pitch is. And for the next matches we will see the same, little by little."