Neto made his long-awaited international debut and Richarlison scored a brace as Brazil eased past minnow El Salvador 5-0.
There were no surprises in Maryland, where captain Neymar converted his second penalty in two games, while Richarlison and Philippe Coutinho were also on target at FedEx Field.
Neymar opened the scoring when El Salvador was harshly penalised for a foul on Richarlison inside two minutes, before the latter capped his starting international debut with a stunning curled effort in the 16th minute, and Coutinho added a third on the half-hour mark.
Richarlison netted his second of the match – the Everton star producing another fine finish past Henry Hernandez five minutes into the second half – and Marquinhos completed the rout in the 90th minute.
All eyes were on goalkeeper Neto, however, after the 29 year-old ended his wait for a senior appearance.
Fans barely had a chance to take their seats when Neymar stepped up and scored from the spot after Richarlison went down under a challenge from El Salvador's Roberto Dominguez in the second minute.
Neymar's opener took his international tally to 59 – three adrift of Ronaldo and 18 behind all-time leading scorer Pele.
It was routine for Brazil – which defeated the United States 2-0 last week – as Richarlison got himself on the scoresheet with a beautiful first-time shot from the edge of the area.
Neymar should have made it 3-0 six minutes later but his shot rattled the crossbar, though, Brazil eventually got its third in the 30th minute via Coutinho, who left the keeper stranded having received a ball from the former just outside the penalty box.
El Salvador emerged from the interval with renewed enthusiasm and attacking intent, and it caused some nervy moments for Brazil, however, it left the CONCACAF nation exposed in defence.
Richarlison was at it again in the 50th minute, firing a low shot into the bottom corner of the net as he showcased his goalscoring instincts, before Marquinhos headed home Neymar's corner at the death.