Paris Saint-Germain will be patient with Neymar's recovery from injury, manager Thomas Tuchel said.
Pablo Sarabia's header 10 minutes from time ensured Paris Saint-Germain did just enough to beat Ligue 2 side Lorient 1-0 and book its place in the last 16 of the Coupe de France.
Paris Saint-Germain will travel to Lorient in the last 32 of the Coupe de France.
Robert Moreno got off to a victorious start as Monaco coach thanks to Benjamin Lecomte's late penalty save and Keita Balde Diao's 95th-minute winner in a Coupe de France clash against Reims.
Reunion-based amateur side Saint-Pierroise pulled off a huge shock in the Coupe de France round of 64 by beating Ligue 2 club Niort on Sunday (AEDT).
Saint-Etienne will feature in a first Coupe de France final since 1982 after defeating Rennes 2-1.