Cameroon failed to find the net during a first half which they dominated, but Hugo Broos' side held firm at the back and punished Ghana deep into the second period to confirm a repeat of the 2008 final that Egypt edged 1-0.
After a rather pragmatic approach to its quarter-final triumph over Senegal, Cameroon posed significantly more attacking threat to Ghana, with wingers Benjamin Moukandjo and Bassogog particularly prominent.
It failed to make the most of its superiority in the first half, though, and Ghana improved after the break to become the controlling force.
But Avram Grant's side endured similar woes in front of goal and their profligacy was punished by Ngadeu-Ngadjui 18 minutes from time – the defender pouncing on a defensive mix-up.
Ghana poured men forward in desperate fashion towards the end and that played into Cameroon's hands, as it added a second thanks to Bassogog in stoppage time, with the Indomitable Lions hoping to claim a first continental title since 2002.