A thigh injury will sideline veteran striker Miroslav Klose for three matches, Lazio confirmed.

Klose suffered the injury during Lazio's 1-0 UEFA Champions League play-off win over Bayer Leverkusen on Wednesday (AEST), substituted at half-time in Rome.

The 37 year-old German will miss next week's return leg, as well as Lazio's opening two Serie A fixtures against Bologna on sunday (AEST) and Chievo on 30 August.

"The outcome of the tests on Klose was what we expected," team doctor Stefano Salvatori told Lazio Style Radio 89.3 FM.

"The German has suffered a muscular lesion to the biceps femoris in his left thigh. He will not be available for the next three matches.

"After the international break we will conduct more tests to more accurately estimate his recovery time."