Karim Benzema could reportedly miss up to six weeks after Real Madrid confirmed the striker suffered a hamstring injury against Levante.
Benzema was substituted in the 24th minute of Madrid's 1-1 draw, after over-stretching in an attempt to control a pass.
Zinedine Zidane's much-changed side laboured to its second home draw of the season, as Lucas Vazquez cancelled out Ivi's surprise opener, with Marcelo dismissed late on to compound Madrid's frustration.
Reports in Spain have suggested Benzema could miss more than a month and, while that has yet to be confirmed, he is almost certain to miss Madrid's UEFA Champions League opener against APOEL on Thursday (AEST).
A Madrid statement read: "[After] tests carried out on Karim Benzema at the Sanitas La Moraleja University Hospital, he has been diagnosed with a muscular injury in the semimembranosus of his right leg.
"His recovery will continue to be assessed."
Real Madrid manager Zinedine Zidane was refusing to panic, however, despite Benzema's absence leaving Madrid short of attacking options having sold Alvaro Morata to Chelsea and failing to land a replacement during the past the transfer window.
"We cannot change that now. We have the squad that we have. We will find solutions with what we have here," Zidane said.
"One goal today is not enough. With the chances we created, we must be more effective.
"We cannot be happy with what we did. Against Valencia we dropped two points, but played well.
"We did not play a good game, clearly. We were better after the break, made chances to score, but it was not a good game."