Robert Lewandowski's late strike ensured 10-man Bayern Munich secured a 2-1 victory over Hoffenheim after Kevin Volland had scored the joint-fastest goal in Bundesliga history.

Hoffenheim headed into the clash at the Rhein-Neckar-Arena looking for its first win over Bayern in 15 attempts and they could not have wished for a better start as Volland netted after only nine seconds - equalling the record set by Bayer Leverkusen's Karim Bellarabi a year ago on Monday (AEST).

Volland took advantage of a stray pass from David Alaba to lash home and stun the champion, but Pep Guardiola's side responded and Manchester United transfer target Thomas Muller equalised with his knee before half-time.

Muller hit the woodwork twice and Arturo Vidal struck the crossbar as Bayern dominated, but the visitor was reduced to 10 men when Jerome Boateng was shown a second yellow card for handball 17 minutes from time - also giving away a penalty.

Eugen Polanski hit the post with resulting spot-kick and substitute Lewandowski added insult to injury by scoring the winner a minute from time to make it two Bundesliga wins out of two for Bayern and deny the host its first point.

There was also a dramatic finale at the Imtech Arena, where Johan Djourou's first goal for Hamburg snatched a 3-2 victory over 10-man Stuttgart. 

Hamburg was hammered 5-0 by Bayern in its Bundesliga opener and looked set for another defeat when Daniel Ginczek struck twice in the first half either side of Ivo Ilicevic's equaliser.

Stuttgart was rocked by Florian Klien's dismissal for a second bookable offence eight minutes into the second half, but it remained in front until Pierre-Michel Lasogga levelled six minutes from time.

Djourou completed the turnaround in the 89th minute to stun the visitor, which has lost both of its opening two matches.

Wolfsburg coach Dieter Hecking refused to lay the blame for his side's 1-1 draw at Cologne on talk of Kevin De Bruyne moving to Manchester City.

City is reportedly closing in on the Belgium international, who played the full 90 minutes on Sunday (AEST), but Hecking stressed that was not the reason for a below-par display after Nicklas Bendtner rescued a point six minutes from the end.  

"I don't see how that is affecting us. You cannot blame a bad game only on one player. So I do not see a correlation," Hecking said.

Hakan Calhanoglu scored the only goal of the game as Bayer Leverkusen made it two wins out of two by seeing off Hannover, while Schalke was held to a disappointing 1-1 home draw by Darmstadt.

Marco Russ's late goal salvaged a 1-1 draw for Eintracht Frankfurt at home to Augsburg.