Aguero was expected to feature in his side's FA Cup clash with Birmingham City at the Etihad Stadium after recovering from knee and hamstring problems.

However, he was not in the matchday squad, with Gabriel Jesus starting the 3-0 victory over the Championship side.

Manager Pep Guardiola later confirmed that the 32 year-old is isolating despite returning a negative test for COVID-19.

"Unfortunately, he was in contact more than usual with one person who is positive," Guardiola said. "He must isolate for a few days.

"I don't know exactly because he has been tested like all of us six times in the last 10-15 days so it is negative. Today I think he was negative too but the protocols says in some cases isolate, and in other cases we still play football.

"He was not able to play today."

Aguero, whose contract expires at the end of the season, has only made three starts for City in all competitions in 2020-2021.

In his absence, two goals from Bernardo Silva and another from Phil Foden secured City's place in the fourth round of the cup.

Guardiola's men return to Premier League action at home to Brighton and Hove Albion on Thursday (AEDT) and host Crystal Palace next Monday (AEDT).