Wasps beat Ulster to help Saracens into the last eight of the European Champions Cup.
Iain Henderson is expected to miss the majority of Ireland's Six Nations campaign after undergoing surgery to repair a torn thumb ligament.
Holder Leinster suffered its first defeat of the 2018/2019 European Rugby Champions Cup as Toulouse produced a stunning finish to snatch a 28-27 victory in Pool 1.
Toulon's miserable start to the European Champions Cup continued as Edinburgh stormed to a 40-14 bonus-point Pool 5 victory, while Wasps and Bath played out a thrilling 10-try draw.
Freddie Burns apologised for a costly late gaffe in Bath's 22-20 defeat to Toulouse which left him at an "ultimate low" and Exeter Chiefs were held by Munster in the European Champions Cup.
Leinster confirmed the signing of Australia attacker Joe Tomane on a two-year deal from Montpellier.
Johnny Sexton conceded "we did it the hard way" after Leinster left it late to beat Racing 92 and secure a record-equalling fourth European Champions Cup title.