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Kieran Dowell hit a hat-trick for Wigan, who remarkably led Hull 7-0 at half-time. Wigan sits in mid-table but is fighting for survival in the second tier because of an administration penalty hanging over the club, and this result was a huge step towards safety.
The only saving grace for Hull, and frustration for Wigan, was that no supporters were present to witness one of the most eye-catching results in English football all season.
Wigan savagely picked apart the free-falling Tigers and climbed to 13th place in the division.
It became the first team to score seven or more goals in one half of a match in either the Premier League or the three tiers of the EFL since Watford came from 2-0 down to beat Blackpool 7-2 with a second-half flurry in January 2015.
Aside from Dowell's treble, Kieffer Moore netted twice and there were goals for Kal Naismith, who set the ball rolling in the first minute, Jamal Lowe and Joe Williams.
Wigan stands to receive a 12-point punishment for entering administration, a troubling development that followed a recent takeover of the club, but they are fighting to avoid that meaning relegation.
The win neatly moved it 12 points clear of Hull, who sit 22nd and are a point adrift of safety, with the Tigers having a suddenly vastly inferior goal difference to Wigan.
West Brom has looked on track for automatic promotion for weeks, but a slip in form from Slaven Bilic's men could see Brentford pip them at the post.
Second-placed West Brom could only draw 0-0 at home against fourth-placed Fulham, meaning Brentford can close to within a point of the Baggies with two rounds of games remaining should they beat Preston North End on Thursday (AEST).