Messi was named in the starting line-up for Argentina's final Group A fixture on Tuesday (AEST), surpassing former team-mate Javier Mascherano with his 148th international cap.
Argentina captain Messi is still chasing an elusive major honour in international colours, a fact somewhat at odds with his gloriously decorated career at LaLiga powerhouse Barcelona.
Nevertheless, as he represents La Albiceleste for the 148th time, the 34-year-old should also reflect upon a brilliant body of work, where he has typically set new standards – most notably standing as Argentina's all-time record goalscorer with 73.
Here, Stats Perform takes a look at Messi's Argentina career in numbers.
CONMEBOL'S SCHOOL OF HARD KNOCKS
In the eternal argument between fans of Messi and Cristiano Ronaldo, the Portugal superstar's international record is sometimes held up as a point of difference.
Ronaldo pulled level with Ali Daei's all-time record of 109 goals for his country during the reigning European champions' 2-2 draw with France at Euro 2020 last week.
But there are a collection of "gimme" opponents afforded to Ronaldo within the European qualifiers that Messi simply does not enjoy.
The arduous CONMEBOL World Cup qualification marathon means plenty of his Argentina caps have arrived against high-quality opposition.
The highest proportion of his caps have come in South American World Cup qualifiers, where he has featured 50 times. This is set against 30 Copa outings, 19 appearances at the World Cup and 47 caps in international friendlies.
HIGH FIVES, BRILLIANT TREBLES
Argentina's bitter rivals Brazil, Paraguay and their 2015 and 2016 Copa America final tormentors Chile have faced up to Messi more than any other nation.
He has played them all 11 times, scoring five goals versus each. Against Bolivia, he will be aiming to improve upon a record of three goals from nine outings, with La Paz's sapping altitude pleasingly not a factor for Messi on this occasion.
Three of those strikes versus Brazil came in one sparkling 4-3 friendly win at New Jersey's MetLife Stadium in 2012.
Overall, he has six international hat-tricks and none more telling than the sensational salvo to secure a 3-1 win away to Ecuador that virtually single-handedly dragged Argentina to Russia 2018.
NIGHTMARE START AND OTHER MILESTONES
Messi's extended run at the summit of world football was not so easy to predict when he marked his Argentina debut from the bench against Hungary in Budapest in 2005 with a red card almost immediately after coming on.
His first goal came against Croatia in Basel on cap number six, while the otherwise forgettable 2010 World Cup quarter-final defeat to Germany in Cape Town was Messi's 50th cap.
Cap 100 came against guest participants Jamaica in the 2015 Copa America, a campaign that ended in now familiar disappointment.