The Selecao head into this year's tournament looking to break a two-decade hold by European nations on the sport's top prize, having been the last country from outside the continent to triumph at the South Korea and Japan 2002 finals.
Tite's side has slightly stretched its points advantage above second-placed Belgium, whom it displaced atop the list in March.
Brazil and Belgium head up an unchanged top five, with Argentina remaining at number three, World Cup holder France at four and England – which endured a dismal 2022 – in fifth place.
The Three Lions will top the strongest group at Qatar 2022, Group B, when taken on points, with fellow nations United States, Wales and Iran all ranked inside the top 20.
Italy, the highest-ranked nation not qualified for the World Cup, forced the only move inside the FIFA top 10 as it heads to sixth from seventh in a straight swap with Spain.
The Netherlands, Portugal and Denmark round out the top 10, with Germany just beyond them at number 11, ahead of 2018 World Cup finalist Croatia.
The lowest-ranked side at this year's tournament will be Ghana, who sit at 61st on the FIFA list, while host Qatar is in 50th place.