Lyon's trip to Toulouse on Saturday has been postponed following advice from regional police.
The Prefecture de Haute-Garonne called for the Ligue 1 match to be called off in the wake of protests in Toulouse.
According to officials, 57 people, including 48 police officers, were wounded on December 1 after clashes with what they described as "violent demonstrators".
⚠️— Toulouse FC (@ToulouseFC) December 4, 2018
Le match de la 17ème journée de @Ligue1Conforama, #TFCOL, initialement prévu ce samedi 8 décembre à 20 heures, est reporté à la demande de la Préfecture.
Une nouvelle date sera fixée prochainement.
➡️ https://t.co/M3mK9HuafF pic.twitter.com/hXOR9530om
Sixteen people were arrested, four of whom were detained after two shops were looted in the city centre.
The decision comes after Paris Saint-Germain's match at home to Montpellier was also cancelled amid continued unrest in the French capital.
The trouble began as a response to rising fuel tax and has led to ugly confrontations on the streets, with police using tear gas, stun grenades and water cannon on the Champs-Elysees.
Three people have been killed since the demonstrations started last month, according to the latest figures, though the country has not declared a state of emergency.