Raphael Varane will miss Real Madrid's LaLiga clash with Sevilla on Saturday through injury, adding to Zinedine Zidane's defensive concerns.

Centre-back Varane walked off the pitch in the 38th minute of Madrid's 3-2 Champions League victory over Borussia Dortmund on Wednesday with what appeared to be a muscular issue.

The loss of the 24-year-old for the visit of Eduardo Berizzo's side, level with Madrid on 28 points in LaLiga, is a bitter blow for Zidane, who will be without suspended trio Sergio Ramos, Dani Carvajal and Casemiro, while Cesar Vallejo is injured.

"He hurt himself and we will see. Tomorrow [Thursday] they will do a scan. The player is optimistic but he will not be available on Saturday, that's for sure," said Zidane, before admitting midfielder Marcos Llorente may have to slot into the back four.

"It could happen. He already knows that position. He played it for Castilla some times."

Following their clash with Sevilla, Los Blancos travel to the Middle East for the Club World Cup before returning to take on Barcelona in El Clasico.

With so many important games approaching, Ramos is concerned by the number of his team-mates being suffering from physical ailments.

"[Varane's injury] is the only bad news from the game, another injury," he told beIN SPORTS.

"This season we are getting too many [injuries]. The season is long and it is preferable to have everyone available for the next game.