It was a day to forget for Seattle Sounders, who had Clint Dempsey dismissed following a video review in the first half on Sunday.
MLS titleholders Toronto lost back-to-back matches in the league following Saturday's 1-0 defeat at Canadian rivals Montreal Impact.
Goals from Anton Tinnerholm and David Villa helped New York City past LA Galaxy in MLS.
LAFC continued where they left off Saturday, crushing hosts RSL thanks to Diego Rossi's brace and a goal from Carlos Vela.
Hollywood star and co-owner Will Ferrell was in attendance as MLS debutants LAFC stunned Seattle Sounders 1-0 on Sunday.
With his impending retirement, here's a look back at Kaka's Orlando City moments