MLS Cup champions Toronto were beaten at Tigres UANL but still moved into the CONCACAF Champions League semi-finals.
Goals from Anton Tinnerholm and David Villa helped New York City past LA Galaxy in MLS.
LAFC continued where they left off Saturday, crushing hosts RSL thanks to Diego Rossi's brace and a goal from Carlos Vela.
Hollywood star and co-owner Will Ferrell was in attendance as MLS debutants LAFC stunned Seattle Sounders 1-0 on Sunday.
Goals from Federico Higuain and Gyasi Zardes saw Columbus Crew upset Toronto in MLS.
With his impending retirement, here's a look back at Kaka's Orlando City moments