New York City overcame the New York Red Bulls thanks to Maximiliano Moralez's late goal.
Josef Martinez tied the single-season goalscoring record with Atlanta United's opening goal against Columbus Crew on Sunday.
New York Red Bulls earned top spot in the Eastern Conference courtesy of a late equaliser, as FC Dallas ended a short losing streak.
Wayne Rooney continued his red-hot form by scoring twice against Portland Timbers at Audi Field in Washington on Wednesday.
A late deflected striker from substitute Niki Jackson caused LA Galaxy to drop points at home to the lowly Colorado Rapids in MLS.
Wayne Rooney produced a moment of magic in the 96th minute to stop Orlando City and lift DC United to a dramatic 3-2 victory.