Dele Alli was sent off as Tottenham crashed out of the Europa League with a 2-2 draw against Gent in the second leg of their last-32 tie on Thursday.

The England international was given his marching orders for a shocking tackle on Brecht Dejaegere towards the end of the first half, and although Spurs battled boldly in his absence, they were unable to secure what would have been only a second win in seven matches at Wembley.

Trailing 1-0 from the first leg, Mauricio Pochettino's side made an ideal start when Christian Eriksen opened the scoring with just 10 minutes played, but a Harry Kane own goal put Gent back in front on aggregate.

Alli's dismissal left Spurs with a mountain to climb but they remained the dominant force after the break, and Victor Wanyama restored their advantage on the night with a blistering strike on the hour mark.

Moses Simon spurned the chance to make Gent's progress all-but safe with 17 minutes to play, but Hein Vanhaezebrouck's side - who are eighth in Belgium's top flight - at last booked their place in Friday's last-16 draw thanks to Jeremy Perbet's finish from a counter-attack.

Spurs now turn their attention to Sunday's Premier League match with Stoke City, as they look to secure a return to Champions League football for next season.

Pochettino had challenged his players to prove they are ready to perform on the big occasions, and it did not take long for them to level the aggregate scores.

Eric Dier's hopeful punt forwards caused havoc in the Gent defence and Eriksen pounced to slide the ball beneath Lovre Kalinic and into the net from the edge of the six-yard box.

Spurs were firmly in the ascendancy but Wembley was stunned 10 minutes later when Gent snatched a valuable away goal in unlikely circumstances, with Kane heading into his own net as he tried to clear following a corner.

The home side's task became that much harder when Alli, frustrated at not winning a free-kick, jumped into an appalling scissor-challenge on Dejaegere to earn a straight red card six minutes before the break.

Undaunted by their numerical disadvantage, Spurs piled pressure on the Gent goal after the break, with Eriksen denied a second only thanks to a timely dash from his line from Kalinic to intercept Kane's clever throughball.

Kane wasted a glorious chance to give Spurs a lifeline, blasting wide of the right-hand post after Eriksen had sent him through on goal, as the home fans around Wembley began to grow frustrated.

Hope was rekindled after 61 minutes, however, as Wanyama fired an unstoppable strike into the top-left corner from the edge of the area after Eriksen flicked the ball into his path.

Kyle Walker came close to a third but Simon missed a clear chance to give Gent a second away goal, heading into the side-netting when picked out unmarked at the far post by Kenny Saief.

Spurs piled on the pressure in the closing stages but Gent made their passage safe in the 82nd minute with their first shot on target, with substitute Perbet reacting quickest to Kalifa Coulibaly's deflected centre to prod the ball beyond Hugo Lloris' left hand and into the bottom-right corner.

Europa League round of 32 second leg results:

Osmanlispor (TUR) 0 Olympiakos (GRE) 3 (Ansarifard 47, 86, Elyounoussi 70)
Olympiakos go through 3-0 on aggregate
                  
Ajax (NED) 1 ((Viergever 49) Legia Warsaw (POL) 0 
Ajax go through 1-0 on aggregate
                  
APOEL (CYP) 2 (Sotiriou 46, Gianniotas 54-pen) Athletic Bilbao (ESP) 0
APOEL go through 4-3 on aggregate
                  
Zenit Saint Petersburg (RUS) 3 (Giuliano 24, 78, Dzyuba 72)  Anderlecht (BEL) 1 (Thelin 90)
Aggregate 3-3 - Anderlecht go through on away goals
                  
Roma (ITA) 0 Villarreal (ESP) 1 (Borré Amaury 16)
Roma go through 4-1 on aggregate
                  
Besiktas (TUR) 2 (Aboubakar 17, Tosun 87) Hapoel Beer-Sheva (ISR) 1 (Nwakaeme 64)
Besiktas go through lead 5-2
                  
Fiorentina (ITA) 2 (Kalinic 15, Borja Valero 29) Borussia Moenchengladbach (GER) 4 (Stindl 44-pen, 47, 55, Christensen 60)
Moenchengladbach go through 4-3 on aggregate
                  
Sparta Prague (CZE) 1 (Karavaev 84) Rostov (RUS) 1
(Poloz 13)
Rostov go through 5-1 on aggregate 
                  
Tottenham Hotspur (ENG) 2 (Eriksen 10, Wanyama 61) Gent (BEL) 2 (Kane 20-o.g., Perbet 82)
Gent go through 3-2 on aggregate
                  
Copenhagen (DEN) 0 Ludogorets (BUL) 0
Copenhagen go through 2-1 on aggregate
                  
Genk (BEL) 1 (Pozuelo 67) Astra Giurgiu (ROM) 0 
Genk go through 3-2 on aggregate
                  
Lyon (FRA) 7 (Fekir 5, 27, 78, Cornet 17, Darder 34, Aouar 87, Diakhaby 89) AZ Alkmaar (NED) 1 (García 26)
Lyon go through 11-2 on aggregate 
                  
Shakhtar Donetsk  (UKR) 0 v 2 (Iago Aspas 90, Gustavo Cabral 108) Celta Vigo (ESP)
Celta Vigo go through 2-1 on aggregate 
                  
Played Wednesday
Saint-Etienne (FRA) 0 Manchester United (ENG) 1 (Mkhitaryan 16)
(United win 4-0 on aggregate)
                  
Schalke (GER) 1 (Schopf 23) PAOK (GRE) 1 (Nastasic 25-og)
Schalke win 4-1 on aggregate
                  
Fenerbahce (TUR) 1 (Souza 41) Krasnodar (RUS) 1 (Smolov 7)
(Krasnodar win 2-1 on aggregate)