Manchester City are adjusting to a significant blow against their Premier League title defence after confirmation Kevin De Bruyne will be sidelined for around three months with lateral knee ligament damage.

The Belgium midfielder, who was City's stand-out performer on the way to Premier League and EFL Cup glory last season, suffered the injury during a training session this week.

Pep Guardiola has an amply stocked squad from which to find solutions to this conundrum, although there is arguably no like-for-like replacement for De Bruyne's all-round midfield mastery.

Here we look at what fixtures City will have to tackle without their talisman and which rivals at home and abroad might be set to benefit from his absence.

Generous early season run

City already have the scalp of a top-six counterpart in the Premier League this term having breezed past Arsenal 2-0 on the opening weekend. The immediate run of fixtures to come appear straightforward on paper and take out a sizeable chunk of De Bruyne's absence.

Starting with Sunday's home game against Huddersfield Town, Guardiola's men face the promoted sides from this season and last season over a six-match period. Complacency should be guarded against, however. Huddersfield were one of only three teams to avoid defeat at the Etihad Stadium in the Premier League in 2017-18, while City needed penalties to overcome Wolves in the EFL Cup.

Champions League group stage

Whoever City face in the round-robin phase of Europe's elite club competition, each opponent will be buoyed by the prospect of not having to tackle De Bruyne. Game-changing goals against Sevilla, Paris Saint-Germain, Barcelona and Shakhtar Donetsk feature among his body of work in a tournament his employers are yet to tame.

City have won 58.3 per cent of their Champions League games with De Bruyne since he joined from Wolfsburg in 2015. That figure drops to 16.7 per cent – one out of six – in the games he has missed. Guardiola must mastermind an improvement, with the first four group-stage matchdays now out of bounds.

A daunting Anfield task

Even with De Bruyne at their disposal, City generally struggled against Liverpool last season. After a 5-0 romp in the wake of a Sadio Mane red card at the Etihad, the champions lost the subsequent three encounters in the Premier League and a Champions League quarter-final.

This included 4-3 and 3-0 reverses at Anfield, where City have not won since 2003. Jurgen Klopp's side have been tipped by many to present the sternest test to Guardiola's ambition of becoming the first manager to retain England's top-flight crown since Alex Ferguson. The Catalan would have dearly loved to have De Bruyne around for a high-stakes showdown on October 7.

Tottenham away (probably)

The second international break of De Bruyne's scheduled absence – a factor in City's favour – comes after the Liverpool game. They return at home to Burnley before taking on Tottenham. Mauricio Pochettino took four points off Guardiola during the latter's first season in England but City stormed to two impressive wins in 2017-18. De Bruyne scored a stunning solo goal in a 4-1 victory last December.

A trip to a top-four rival remains a significant moment in any title bid, although the October 28 clash is cloaked in uncertainty as Tottenham race to get their new stadium ready. The venue is presently listed as TBC on Spurs' website, with NFL taking place at their temporary home of Wembley on October 27.

Manchester derby return

Injury struck for De Bruyne on August 15 and the timeframe outlined by City for his recovery means attention is quickly drawn to the first Manchester derby of the season on November 11. City v United; Guardiola v Mourinho – it would be the perfect time to reintroduce the playmaker's star quality.