Manchester City will be without influential midfielder Kevin De Bruyne for Wednesday's EFL Cup clash against rivals Manchester United at Old Trafford.

Belgium international De Bruyne was substituted at half-time during Saturday's 1-1 draw at home to Southampton after taking a knock to the calf.

The 25-year-old opened the scoring when City claimed a 2-1 win over United last month but Guardiola told a pre-match news conference he had "no way" of playing in the latest derby showdown.