Trailing 3-2 in the 90th minute, Rafael Caroca and Diego Bielkiewicz scored as hosts Iquique prevailed in a seven-goal thriller on Wednesday (AEST).

It was a topsy-turvy Group 8 clash in the second half after Alvaro Ramos had given host Iquique a 14th-minute lead at Estadio Zorros del Desierto.

Venezuelan visitor Zamora scored twice in 15 minutes via Ricardo Clarke's penalty and Erickson Gallardo to hit the front 2-1 just past the hour-mark.

Caroca then headed past Carlos Salazar in the 82nd minute before Anthony Uribe equalised for Zamora three minutes later.

The drama was not over however, as Caroca completed his brace in the 92nd minute with a stunning strike from outside the penalty area and Bielkiewicz sealed the comeback by rebounding his own effort three minutes later.

Iquique is third in the group after back-to-back wins - a point adrift of Gremio and Guarani - while Zamora is yet to register a point after four matches.

San Lorenzo finally opened its Libertadores account, edging Universidad Catolica 2-1 in Group 4.

Without a win in three matches, San Lorenzo posted its first victory thanks to Nicolas Blandi and Cristian Barrios against Catolica, which ended the game with 10 men after two yellow cards to Benjamin Kuscevic.

Meanwhile, Atletico Tucuman defeated Wilstermann 2-1 in Group 5.