Danny Rose, Gary Cahill, David Luiz, Kyle Walker and Dele Alli are also included, highlighting the impressive consistency of the London clubs.
The three players not from Spurs or Chelsea are Manchester United's David de Gea, Liverpool winger Sadio Mane and Everton's Romelu Lukaku, who is leading the Golden Boot standings with 24.
There is no space for Zlatan Ibrahimovic or Alexis Sanchez, both of whom made the shortlist for the PFA Players' Player of the Year prize.
The PFA best teams for each tier of England's football league, as well as the individual prizes, are voted for by professional players across the divisions.
The award ceremony takes place on Monday.